A comparative study of Acne Vulgaris with special reference to Therapeutic options

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Original Article

Author Details : Sunil Kumar*, Basanti Devi, Veeraoubhadra Goud

Volume : 5, Issue : 4, Year : 2019

Article Page : 306-311

https://doi.org/10.18231/j.ijced.2019.064

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Abstract

Introduction: Acne vulgaris (AV), a human skin disease and commonly seen in adolescence. Affecting
about 80–90% of teenagers in the Western population and lower rate are observed in rural societies. The
present study aimed to compare the therapeutic efficacy of various drugs used in different grades of acne
accordingly.
Materials and Methods: This study prospective comparative study f orty patients with mild degree of
acne were included as group I and 40 patients with moderate degree of acne were considered as group II.
Group I patients were divided into Tretinoin(0.004%) group and Adapalene(0.1% gel). Group II patients
were divided into Clindamycin (1%) group and Clindamycin 1% gel plus Benzoyl peroxide 5% cream. All
these patients were given topical gel as per the dosage schedule over a period of 12 weeks. The change
occurred in acne lesions were recorded every 2 weekly follow-up using global assessment improvement
scale.
Results: Efficacy and cutaneous tolerance were assessed at baseline and 2,4,6,8,10 and 12 weeks. At the
end of 12 weeks treatment, 75% of patients using Tretinoin showed good response to excellent response
and 25% patients showed poor to fair response. At the end of 12 weeks treatment, 80% of patients using
Adapalene showed good to excellent response. There is no significant difference between two groups.
Topical Adapalene is eqally efficacious as Tretinoin. At the end of 12 weeks treatment, 45% of patients
using only Clindamycin showed good to excellent response. While 90% of patients using both Clindamycin
and Benzoyl peroxide showed good to excellent response. Combination of Clindamycin 1% gel with
Benzoyl peroxide cream more efficacious than Clindamycin 1% gel alone in reducing the number of lesions
in grade 2 acne.
Conclusion: The present study showed there is n o significant difference between Adapalene (0.1%) and
Tretinoin (0.04%) after 12 weeks of treatment. Significant reduction in number of inflammatory and total
lesions were demonstrated in patients using combination therapy (Clindamycin plus benzoyl peroxide)
compared with those using only Clindamycin gel in grade 2 acne patients.

Keywords: Tretinoin (0.04%), Adapalene (0.1%), Clindamycin (1%), Benzoyl peroxide (5%).

How to cite : Kumar S, Devi B, Goud V, A comparative study of Acne Vulgaris with special reference to Therapeutic options. IP Indian J Clin Exp Dermatol 2019;5(4):306-311

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