Comparison of oral versus topical tranexamic acid for treatment of melasma

---

Original Article

Author Details : Meetesh Agrawal, Krishnendra Varma, Ujjwal Kumar, Shashank Bhargava, Aishwarya Mahadik, Vishal Agrawal*

Volume : 9, Issue : 2, Year : 2023

Article Page : 84-89

https://doi.org/10.18231/j.ijced.2023.015

Suggest article by email

Get Permission

---

Abstract

Background: Melasma is one of the most common causes of hyperpigmentation and is a prevalent cosmetic concern for patients. Tranexemic acid is an effective mode of treatment available in both oral and topical forms.
Aim: To evaluate and compare the therapeutic effectiveness of topical and oral tranexamic acid for the treatment of melasma.
Materials and Methods: A total of 84 patients who presented to dermatology OPD with melasma were divided into two groups, namely A and B. Group A patients were treated with oral tranexamic acid 250 mg twice daily, and patients in Group B were treated with topical 5% tranexamic acid with follow-up every 4 weeks until 3 months.
Results: Among the oral treatment and topical patient groups, a statistically significant difference in the mean percentage of reduction in MASI score from baseline was observed at 12 weeks (61.31±9.48 for oral vs 52.64±8.03 for topical) with p<0> Conclusion: Oral tranexamic acid gave a more promising result when compared to topical tranexamic acid. Despite having GI disturbances with oral tranexamic acid, it had more patient compliance and could be a promising therapeutic approach for melasma.
 

Keywords: Melasma, Oral tranexamic acid, Topical tranexamic acid, Tranexemic acid, TA

How to cite : Agrawal M, Varma K, Kumar U, Bhargava S, Mahadik A, Agrawal V, Comparison of oral versus topical tranexamic acid for treatment of melasma. IP Indian J Clin Exp Dermatol 2023;9(2):84-89

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.