A case-control study evaluating association of serum vitamin D level with alopecia areata

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Author Details : Sudhanshu Sharma, Abhishek Singh*, Sanjeet Panesar, Bhawna Chaudhary

Volume : 5, Issue : 3, Year : 2019

Article Page : 186-190

https://doi.org/10.18231/j.ijced.2019.040

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Abstract

Introduction: Evidance has suggested that Vitamin D may play a vital role in the pathogenesis of alopecia
areata (AA). Vitamin D may prove as a geme changer in the management of alopecia patients.
Aim: To study find the correlation, if any, between Alopecia areata and levels of Vitamin D.
Materials and Methods: This investigation included 100 cases of alopecia areata with age- and sexmatched
healthy persons. Study subjects were grouped as per extent, pattern and severity of alopecia.
Levels of vitamin D were evaluated and group wise comparision was made between cases and controls.
Correlations were derived after analyzing the collected data.
Results: Mean serum Vitamin D levels was found to be 22.8710.03 ng/ml among cases. Serum Vitamin D
level was found to be 26.0410.06 ng/mL where scalp involvement was between 0%–24%. Levels droped
to 24.63 9.82 ng/mL when scalp involvement was 25%–49%. Levels of Vitamin D further dropped to
11.914.18 ng/mL and 11.914.18 ng/mL where scalp involvement was graded as S4 and S5 respectively.
Negative correlation (r = ???? 0.264) was noted between extent of Alopecia Areata and Vitamin D levels.
Serum Vitamin D level was found to be 25.589.82 ng/mL among subjects graded as having alopecia
circumscripta. Levels of Vitamin D further dropped to 12.28 5.06 ng/mL and 11.27 5.90 ng/mL where
extent of scalp involvement was graded as alopecia totalis and alopecia universalis respectively.
Conclusion: Vitamin D levels were unsatisfactory in the study subjects of group 1(cases) in relation to
subjects of group 2(controls). Vitamin D levels had inverse correlation with the pattern of alopecia in
these patients. Such findings points towards a probable association between alopecia areata and Vitamin D
deficient levels.

Keywords: Casecontrol study, Alopecia areata, SALT score, Vitamin D.

How to cite : Sharma S, Singh A, Panesar S, Chaudhary B, A case-control study evaluating association of serum vitamin D level with alopecia areata. IP Indian J Clin Exp Dermatol 2019;5(3):186-190

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