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Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate
- Author Details:
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Pinar Ozuguz
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M. Sena Ulu
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Seval Dogruk Kacar
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Ufuk Ozuguz
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Semsettin Karaca
Introduction/ Purpose: Mean Platelet Volume (MPV), an indicator of platelet activation, is a new risk factor for atherothrombosis and an important marker for the increase in thromboembolic diseases. MPV/ platelet ratio is considered as a risk factor for various diseases such as myocardial infarction. In this study, we aimed to investigate the possible effect of ISO on blood cell counts especially MPV and MPV/ platelet ratio.
Materials and Methods: 75 patients, between the ages of 18-25 with moderate or severe acne vulgaris and using oral isotretinoin (0.5 mg/ kg) were included in the study. Platelet count and MPV values of patients (pre-treatment and 3 months after the treatment) were recorded retrospectively.
Results: The mean age of patients was 23.32+3.44 years. 40 patients were female and 35 were male. MPV levels and MPV/ p ratio of “before treatment period” were significantly higher than the “after treatment period” (p Conclusion: In the literature, alteration in platelet levels under ISO treatment is a controversial issue. Furthermore, it was emphasized that, ISO treatment may be change platelet functions. In our study, MPV values and MPV / p ratio were decreased after ISO treatment. Our data indicates that, the thromboembolic risk of patients with acne vulgaris may reduce after ISO treatment.
References
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How to Cite This Article
Vancouver
Ozuguz P, Ulu MS, Kacar SD, Ozuguz U, Karaca S. Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate [Internet]. IP Indian J Clin Exp Dermatol. 2015 [cited 2025 Oct 22];1(1):14-16. Available from: https://doi.org/
APA
Ozuguz, P., Ulu, M. S., Kacar, S. D., Ozuguz, U., Karaca, S. (2015). Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate. IP Indian J Clin Exp Dermatol, 1(1), 14-16. https://doi.org/
MLA
Ozuguz, Pinar, Ulu, M. Sena, Kacar, Seval Dogruk, Ozuguz, Ufuk, Karaca, Semsettin. "Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate." IP Indian J Clin Exp Dermatol, vol. 1, no. 1, 2015, pp. 14-16. https://doi.org/
Chicago
Ozuguz, P., Ulu, M. S., Kacar, S. D., Ozuguz, U., Karaca, S.. "Does İsotretinoin (ISO) Therapy İncrease Coagulation Tendency? Evaluation of MPV values and MPV / platelet rate." IP Indian J Clin Exp Dermatol 1, no. 1 (2015): 14-16. https://doi.org/