Association of serum CXCL-10, IL-22 and IL-6 with types of vitiligo - Study conducted at a tertiary care hospital of Tripura

• Author Details:   
• Syamal Kanti Chakraborti
• Bidhan Goswami ^*
• Shauli Sengupta
• Partha Saha

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Background: According to research conducted in India, the prevalence of vitiligo in dermatology outpatients consistently ranges from 0.25 to 4 percent. From previous studies, it has been reported that the serum level of CXCL-10 is increased in organ specific autoimmune diseases, such as type 1 diabetes, Graves’ disease etc. But the role of CXCL10 in the immunopathogenesis of vitiligo has been highlighted in very few studies.

Objectives: To estimate the serum levels of CXCl-10, IL-6 & IL-22 in patients suffering from Vitiligo reporting in Dermatology Outpatient Department and also to find out the association between these serum biomarkers and clinical status of Vitiligo among the study subjects.

Patients and Methods: The study included One hundred forty-two vitiligo patients who were able to comply with the study protocol reported in the Dermatology Outpatient department of a tertiary teaching hospital of Tripura. All recruited patients were subjected to documentation of complete history. Detailed physical examination was performed for type of vitiligo, the distribution and body surface area (BSA) involvement using palm method and rule of nines. 5 ml Blood Samples were taken after getting written consent from the patient or from the legal guardian in case of children for performing tests namely Serum CxCL-10, IL-6, IL-22 etc. Results: Out of 142 vitiligo patients, 66.2% (94) were Female and 33.8% (48) were Male. According to study result maximum Vitiligo patients of Tripura lie within 11-20 years age group (24.65%). The mean serum levels of CXCL10 and IL-22 in the Vitiligo group was statistically higher in patients with Non-segmental type of Vitiligo.

Conclusion: From this study, we can conclude that increased serum levels of CXCL10 is associated with types of Vitiligo where non-segmental type showed maximum level followed by segmental and focal type respectively.