- Visibility 334 Views
- Downloads 160 Downloads
- Permissions
- DOI 10.18231/2581-4729.2018.0029
-
CrossMark
- Citation
A comparative study between the efficacy of 35% glycolic acid peel and triple combination cream in the treatment of melasma
- Author Details:
-
Ameen Basil
-
Madhavi Latha Akula
-
Farzana Najmuddin
-
Narendra J. Shetty
-
Monisha Shetty
Introduction: Melasma is an acquired symmetric hypermelanosis characterized by irregular light to greyish brown macules on sun exposed skin, usually face. It is more seen in women and is more prevalent in individuals with skin type IV, V and VI. The exact etiology of melasma is not known therefore various treatment modalities have been employed. These include topical depigmenting agents like hydroquinone, azelaic acid, retinoids, chemical peels, low and high fluence lasers, yet none have proven to being fully beneficial in our study, we aim at comparing the therapeutic efficacy of 35% glycolic peel and triple combination cream in the treatment of melasma.
Materials and Methods: It is a hospital based study. 60 diagnosed cases of melasma were randomly enrolled equally to two groups P and Q. Group P patients given serial 35% Glycolic acid peel and group Q patients given Triple combination cream to be applied topically once at night daily. Followed up on 4th, 8th and 12th week. At each visit clinical response to treatment was calculated using MASI score.
Results: At 4th, 8th and 12th week post treatment evaluation, Triple combination cream had an overall superiority to serial 35% glycolic acid peel as a topical hypopigmenting agent.
Conclusion: The results of the study show that Triple combination cream is a better hypopigmenting agent with rapid rate of clinical improvement when compared to 35% glycolic acid peel.
Keywords: Melasma, Triple combination cream, 35% Glycolic acid peel.
References
- Balakrishnan .R, Mc Michael AJ, Camacho FT, Saltzberg F, Housman TS, Grummer S; Development and validation of a health related quality of life instrument for women with melasma; Br J Dermatol 2003;149:572-7.
- Pawasker M, Parikh P, Marswoski T, McMichael AJ, Feldman SR, Balakrishnan R; Melasma and its impact on health related quality of life in Hispanics women. J Dermatol 2007;18:5-9.
- Cestari T, Hexsel D, Viegas M, Azulay L, Hassun K, Almeida AR; Validation of a melasma quality of life questionnaire for Brazilian Portuguese language: the melasQol-BP study and improvement of Qol of melasma patients after triple combination therapy; Br J Dermatol 2007;156:13-20.
- Katsambas A, Antoniou C; Melasma: Classification and Treatment. J European Academy Dermatology and venereology 1995;4:217-223.
- Stulberg DL, Clark N; Common hyperpigmentation disorders in Adults; Part II; Melanoma, Seborrheic Keratoses, Acanthosis Nigricans, Melasma, Diabetic Dermopathy, Tinea Versicolor and Post inflammatory Hyperpigmentation. Am Fam Phya 2003;68:1963-8.
- Balakrishnan R; Predictors of Health Related Quality of Life in Women with Melasma; Cosmetic Dermatol 2003;16:25-30.
- Ortonne JP, Arellano I, Berneburg M, Cestari T, Chan H, Grimes P; A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma; J Eur Acad Dermatol Venerol 2009;23:1254-
- Rendon MI; Utilizing combination therapy to optimize melasma outcomes; J Drugs Dermatol 2004;3(S):27-34.
- Grimes PE; Melasma: etiologic and therapeutic considerations; arch Dermatol 1995;131:1453-7.
- Vazquez M, Maldonaldo H, Benaman C, Sanchez JL; Melasma in men: A clinical and histologic study; Int. J Dermatol 1988;27:25-7.
- Nanda S, Grover C, SN Reddy B; Efficacy of hydroquinone (2%) versus Tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma; Dermatol Surg 2004; 30:3-386.
- Pasricha JS, Khaitan BK, Dash S; Pigmentary disorders in India; Dermatol Clin 2007;25:343-522.
- Victor FC, Gelber J, Rao B; Melasma : A Review J Cutan Med Surg 2004;8:97-102.
- Sanchez NP, Pathak MA, Satos S, Fitzpatrick TB, Sanchez JL, Mihm Jr MC; Melasma: A clinical, light microscopic, ultrastructural and immunofluorescence study; J Am Acad of Dermatol 1981;46:698-710.
- Hann SK, Im S, Chung WS, Kim do Y; Pigmentary disorders in the South East; Dermatol Clin 2007;25:431-
- Hughes BR; Melasma occurring in twin sisters; J Am Acad Dermatol, 1987;17:841.
- Resnick S; Melasma induced by oral contraceptive drugs; J Am Med Assoc.1967;199:95-9.
- Pandya AG, Guevara IL; Disordes of hyperpigmentation; Dermatol clin 2000;181:91-8.
- Perez M, Sanchez JL, Aguilo F; Endocrinologic profile of patients with idiopathic melasma; J Invest Dermatol 1983;81:543-5.
- Sialy R, Hassan I, Kaur I, Dash RJ,; Melasma in men : A hormonl profile; J Dermatol 2000;27:64-5.
- Lutfi RJ, Fridmanis M, Misrunas AL; Association of melasma with thyroid autoimmunity and other thyroid abnormalities and their relationship to the origin of melisma; J Clin Endocrinol Metab 1985;61:28-31.
- Piamphongsant T; Treatment of melasma: A review with personal experience; Int J Dermatol 1998;37:897-903.
- Gano SE, Garcia RL; Topical tretinoin, hydroquinone and betamethasone valerate in the therapy of melasma; Cutis 1979;23:239-41. Ameen Basil et al. A comparative study between the efficacy of 35% glycolic acid peel and tripleβ¦.. IP Indian Journal of Clinical and Experimental Dermatology, April-June, 2018;4(2):123-131 131
- Frenk E. Treatment of melasma with depigmenting agents; In: Melasma: New Approaches to Treatment; London: Martin Dunitz Ltd.;1995:9-15.
- Van Scott E, Ditre CM, Yu RJ,; Alpha hydroxyl acids in the treatment of signs of photoageing ; Clin Dermatol 1996 ; 14:27-226.
- Grover C, Reddu B S; The therapeutic value of glycolic acid peels in dermatology; Indian J Dermatol Venereol Leprol 2003;69:148-50.
- Berardesca E, Distante F, Vignoli GP et al; Alpha hydroxy acids modulate stratum comeum barderfunction; Br J Dermatol 1997;137:934938.
- Amer M, Metwalli M ; Topical hydroquinone in the treatment of some hyperpigmentary disorders; Int J Dermatol 1998;37:449-50.
- Haddad AL, Matos LF, Brunstein F, Ferreira LM, Silva A, Costa D; Jr; A clinical, prospective, randomized, double-blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma; Int J Dermatol 2003;42:153-6.
- Taylor SC, Torok H, Jones T, Lowe N, Rich P, Tschen E, ; Efficacy and safety of a new triple-combination agent for the treatment of facial melasma; Cutis 2003;72:67-72
- Neering H; Treatment of melasma (chloasma) by local application of a steroid cream; Dermatologica 1975;151:349-53.
- Kanwar AJ, Dhar S, Kaur S; Treatment of melasma with potent topical corticosteroids; Dermatology 1994;188:170.
- Kligman AM, Willis I; A new formula for depigmenting human skin; Arch Dermatol 1975;111:40-8.
- Dhar S, Dutta P, Malakar R; Pigmentary disorders. In: Valia RG, Valia AR, editors. IADVL textbook of dermatology 3rd ed, Mumbai, India: Bhalani publishing house; 2008 736-98.
- Griffiths CEM, Finkel LJ, Ditre CM, Hamilton TA, Ellis CN, Voorhees JJ; Topical tretinoin (retinoic acid) improves melasma; A vehicle controlled, clinical trial; Br J Dermatol 1993;129:415-21.
- Torok H; A large 12-month extension study of triple ombination cream in melasma pateints previously treated with triple combination cream or one of its dysadvantages; J Drugs Dermatol 2005;4:592-7.
- Sarkar R, Kaur C, Bhalla M, Kanwar AJ; The combination of glycolic acid peels with a topical regimen in the treatment of melasma in dark-skinned patients: A comparative study; Dermatol Surg. 2002;28:828β32.
- Lim JT, Tham SN; Glycolic acid peels in the treatment of melasma among Asian women; Dermatol Surg 1997;23:177β9.
How to Cite This Article
Vancouver
Basil A, Akula ML, Najmuddin F, Shetty NJ, Shetty M. A comparative study between the efficacy of 35% glycolic acid peel and triple combination cream in the treatment of melasma [Internet]. IP Indian J Clin Exp Dermatol. 2018 [cited 2025 Oct 20];4(2):123-131. Available from: https://doi.org/10.18231/2581-4729.2018.0029
APA
Basil, A., Akula, M. L., Najmuddin, F., Shetty, N. J., Shetty, M. (2018). A comparative study between the efficacy of 35% glycolic acid peel and triple combination cream in the treatment of melasma. IP Indian J Clin Exp Dermatol, 4(2), 123-131. https://doi.org/10.18231/2581-4729.2018.0029
MLA
Basil, Ameen, Akula, Madhavi Latha, Najmuddin, Farzana, Shetty, Narendra J., Shetty, Monisha. "A comparative study between the efficacy of 35% glycolic acid peel and triple combination cream in the treatment of melasma." IP Indian J Clin Exp Dermatol, vol. 4, no. 2, 2018, pp. 123-131. https://doi.org/10.18231/2581-4729.2018.0029
Chicago
Basil, A., Akula, M. L., Najmuddin, F., Shetty, N. J., Shetty, M.. "A comparative study between the efficacy of 35% glycolic acid peel and triple combination cream in the treatment of melasma." IP Indian J Clin Exp Dermatol 4, no. 2 (2018): 123-131. https://doi.org/10.18231/2581-4729.2018.0029