Evaluation of safety and efficacy of hydrogen peroxide stabilized cream for treatment of mild to moderate acne vulgaris in comparison with benzoyl peroxide gel - double blinded, randomized control study

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Original Article

Author Details : Meetesh Agrawal, Animesh Saxena*, Aditi Tripathi, Vivek Kumar Dey, Shalini Kushwaha

Volume : 6, Issue : 3, Year : 2020

Article Page : 217-221

https://doi.org/10.18231/j.ijced.2020.044

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Abstract

Acne is defined as a chronic inflammatory disorder of the pilosebaceous unit, which is characterized by comedones, seborrhea, pustules, nodules, pseudocysts and scarring, in some cases. Benzoyl peroxide (BP) is a time tasted molecule in the management of acne. In current study we have tried to compare efficacy of benzoyl peroxide with hydrogen peroxide (HP) in acne vulgaris (AV).
Aims: To study efficacy and local tolerability of BP and HP in Acne Vulgaris treatment. To compare the efficacy and local tolerability of BP gel and HP cream in a Acne Vulgaris (GRADE 1 AND 2) treatment. 
Materials and Methods: A double blinded, randomised control study for the duration of 18 months was carried out in which a total of 150 patients of acne vulgaris (Grade 1 & 2) between the age of 13-30 years of both genders were recruited, which were divided in two groups, with one group treated with benzoyl peroxide gel 2.5% and second group being treated with hydrogen peroxide cream. All the data analysis was done using IBM SPSS ver. 20 software.
Results: Both drugs were found to be equally efficacious in reducing acne lesions. Hydrogen peroxide group experienced less side-effects as compared to benzoyl peroxide group.
Conclusion: Hydrogen peroxide and benzoyl peroxide are equally efficacious.
Key Messages: In acne grade one and two benzoyl peroxide and hydrogen peroxide are equally efficacious though hydrogen peroxide has less adverse effect.

Keywords: Acnevulgaris, Benzoyl peroxide Hydrogen peroxide.

How to cite : Agrawal M, Saxena A, Tripathi A, Dey V K, Kushwaha S, Evaluation of safety and efficacy of hydrogen peroxide stabilized cream for treatment of mild to moderate acne vulgaris in comparison with benzoyl peroxide gel - double blinded, randomized control study. IP Indian J Clin Exp Dermatol 2020;6(3):217-221

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