A real-world observational study to evaluate the safety & effectiveness of Naftifine 2% cream in patients with superficial fungal skin infection

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Original Article

Author Details : Kiran Godse, T S Vidya, Pankaj Adhikari, AK Prasad, Chinmoy Raj, Gaurav Bhaskar, Arjun Mapare, Ashok D Jaiswal, Monika Chinda*

Volume : 10, Issue : 3, Year : 2024

Article Page : 260-265

https://doi.org/10.18231/j.ijced.2024.046

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Abstract

Background: Naftifine hydrochloride, an allylamine, is a topical agent used in treating superficial fungal infections, especially dermatophytosis. The objective of this study was to assess the safety and effectiveness of naftifine 2% cream in Indian patients with superficial fungal skin infection.
Aim: A real-world observational study to evaluate the safety & effectiveness of Naftifine 2% cream in patients with superficial fungal skin infection.
Materials and Methods: It was an open-label, multi-centric, observational, prospective real-world study conducted on Indian patients, where subjects were advised to apply naftifine 2% cream on the affected area at the discretion of the treating physician. Effectiveness was determined by assessing the clinical cure (absence of signs and symptoms) and/or mycological cure (negative microscopic KOH test) at the end of the treatment. Safety & tolerability were evaluated based on the presence of adverse events and their severity. The patient compliance was recorded based on the investigator's assessment.
Results: A total of 463 patients were enrolled in the study, out of which 82.07% achieved a clinical cure at the end of the treatment. The skin scraping for microscopic KOH mounting was available for 94 patients out of which the mycological cure was observed in 89 patients (94.6%) (p<0> Conclusion: Topical Naftifine 2% cream was safe and effective in Indian patients with tinea cruris and tinea corporis.
 

Keywords: Naftifine, Allylamines antifungal, Tinea cruris, Tinea corporis, Dermatophytosis

How to cite : Godse K, Vidya T S, Adhikari P, Prasad A, Raj C, Bhaskar G, Mapare A, Jaiswal A D, Chinda M, A real-world observational study to evaluate the safety & effectiveness of Naftifine 2% cream in patients with superficial fungal skin infection. IP Indian J Clin Exp Dermatol 2024;10(3):260-265

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